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Meenhard Herlyn, D.V.M., D.Sc., is a researcher who works as director of The Wistar Institute Melanoma Research in Philadelphia.〔(【引用サイトリンク】url=http://www.wistar.org/our-science/scientists/meenhard-herlyn-dvm-dsc )〕〔(【引用サイトリンク】url=http://wistar.org/news-and-media/press-releases/the-wistar-institute-launches-new-melanoma-research-center )〕〔(【引用サイトリンク】url=http://www.reachmd.com/xmradioguest.aspx?pid=132917 )〕〔(【引用サイトリンク】url=http://www.penncancer.org/patients/find-a-doctor/145/ )〕 His primary research focus is the underlying biology behind melanoma, the most aggressive form of skin cancer. Over the course of his career, he has been responsible for the use of three-dimensional artificial skin cultures to study tumor and normal cells, a clearer understanding of stem cells and how they relate to cancer, and signaling pathways related to cancer.〔(【引用サイトリンク】url=http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2010.00683.x/pdf )〕 The Wistar Melanoma (WM) cell lines that Herlyn has used and helped discover in his laboratory are responsible for a better understanding of the major steps of tumor progression in human cases of melanoma. In 2003, Herlyn helped launch the first International Melanoma Research Congress in Philadelphia, the first scientific meeting specifically aimed at melanoma scientists. This was done in collaboration with the Foundation for Melanoma Research. This collaboration was prompted with his first direct melanoma patient interaction after more than two decades of research on the disease.〔(【引用サイトリンク】url=http://www.the-scientist.com/?articles.view/articleNo/26327/title/A-life-behind-life-science/ )〕 He also established the Society for Melanoma Research in 2004 and served as its president for three years.〔(【引用サイトリンク】url=http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2010.00683.x/pdf )〕 One of the more recent discoveries made by Herlyn's lab found that the diabetes drug phenformin could be used to treat certain slow-growing, drug-resistant tumor cells in melanoma.〔(【引用サイトリンク】url=http://www.cancercommons.org/2013/06/21/diabetes-plus-anticancer-drug-combination-targets-melanoma-cells-unresponsive-to-standard-treatments/ )〕 In December 2013, it was announced that Herlyn and his colleagues had received a five-year, $12.5 million program project grant (PO1) to continue research on melanoma from multiple angles.〔(【引用サイトリンク】url=http://wistar.org/%20news-and-media/press-releases/five-year-research-grant-tackles-melanoma )〕 In May 2013, L'Oréal Paris announced that Herlyn would lead the Melanoma Research Alliance Team Science Award, which provides more than $750,000 over three years to research the prevention, treatment, and potential cures for melanoma.〔(【引用サイトリンク】url=http://www.drugstorenews.com/article/lor%C3%A9al-paris-teams-melanoma-research-alliance-battle-melanoma )〕 ==Select publications== * Balaburski, G.M., Leu, J.I., Beeharry, N., Hayik, S., Andrake, M.D., Zhang, G.,Herlyn, M., Villanueva, J., Dunbrack, R.L., Yen, T., George, D.L., Murphy, M.E.: A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol. Cancer Res. 11:219-229, 2013. * Krepler, C., Chunduru, S.K., Halloran, M.B., He, X., Xiao, M., Vultur, A., Villanueva, J., Mitsuuchi, Y., Neiman, E.M., Benetatos, C., Nathanson, K.L., Amaravadi, R.K., Pehamberger, H., McKinlay, M., and Herlyn, M.: The novel SMAC inhibitor birinapant exhibits potent activity against human melanoma cells. Clin. Cancer Res. 19: 1784-1794, 2013. * Desai, B.M., Villanueva, J., Nguyen, T-T.K., Lioni, M., Xiao, M., Kong, J., Krepler, C., Vultur, A., Flaherty, K.T., Nathanson, K.L., Smalley, K.S.M., Herlyn, M.: The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling. PLoS One, 8(3):e59588 doi:10:1371/journal.pone.0059588, 2013. * Vultur, A., Villanueva, J., Krepler, C., Rajan, G., Chen, Q., Li, L., Gimotty, P., Wilson, M., Hayden, J., Keeney, F., Nathanson, K.L., Herlyn, M. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Oncogene April 29 (ahead of print ), 2013. * Aird, K.M., Zhang, G., Li, H., Tu, Z., Bitler, B.G., Garipov, A., Wu, H., Wei, Z., Wagner, S.N., Herlyn, M., Zhang, R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 3:1-4, 2013. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Meenhard Herlyn」の詳細全文を読む スポンサード リンク
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